KMID : 0381919970270010057
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Korean Journal of Microscopy 1997 Volume.27 No. 1 p.57 ~ p.70
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Ultrastructural Observations of Glutamatergic Synaptic Components in the Basilar Pontine Nuclei of the Dog
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Lee Hyun-Sook
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Abstract
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The distribution of glutamatergic synaptic structures in the dog basilar pons was investigated at the ultrastructural level using monoclonal antibodies against fixative-modified glutamate. Electron-dense reaction product was densely localized at the perinuclear region in the neurenal somata and often observed along the microtubules located within the dendritic processes. One or more unlabelled axon terminals made asymmetric synaptic contacts with glutamate-immunoreactive dendritic profiles. In audition, reaction product was observed either within axonal processes surrounded by myelin sheath or axon terminals. Immunoreactive axon terminals made asymmetric synaptic contact either with unlabelled or labelled dendritic profiles. These observations provided an anatomic evidence of how this excitatory neural element might perform its function in a multisynaptic pathway involving glutamatergic afferents to the basilar pons, glutamate-immunoreactive pontocerebellar projection neurons, and the glutamate-positive granule cells of the cerebellar cortex.
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KEYWORD
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Basilar pons, Glutamate, Immunocytochemistry
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